If you are familiar with anime and Manga, then naming the best "Naruto Shippuden" characters should not be hard. Masashi Kishimotois the originator of the Naruto series. The animated series is based on a boy named Naruto as he strives to become the leader of his village. In this world of ninjas and renegades, choosing the best "Naruto Shippuden" characters is difficult but here’s an attempt.
Naruto is a member of team Kakashi that hold the spirit of a nine-tailed fox inside him. Uzumaki Naruto has conquered his lonesome childhood by acquiring many friends. He is one of the best of "Naruto Shippuden" characters because he is persistent in his quest to become a Hokage.
Orochimaru is one of the main rivals against his home village and leader of Otogakure, his own ninja community. He likes to perform experiments on humans and wants to learn all types of jutsu. Orchoimaru resembles and uses snakes during combat, that reason is why he is one of the best characters.
She is the girl ninja of the "Naruto Sippuden" characters and a leaf team mate of Naruto. In this series, she has given up on her crush, Uchiha Sasuke, when he leaves the leaf village. Sakura has matured since the beginning of the series and has received healing ninja training from the Fifth Hokage, Tsunade.
Sauske is a former friend and teammate of Naruto and Sakura. In "Naruto Shippuden", he leaves his friends and village behind to find and kill his brother. Sauske joins Orochimaru to gain the skills to kill his brother for murdering their family.