Drug use in movies is nothing new. But for some films, your regular, run of the mill drugs like pot and cocaine just don’t cut it. That’s when it’s time to break out the hard stuff. In fact, the following movie drugs are so hardcore, they don’t even exist.

9. NZT – Limitless

In Limitless (In theaters March 18th), Eddie Morra is a down and out writer who decides to try his luck with an experimental drug known as NZT. The drug works wonders, unlocking the full potential of his brain, leading to his rapid acquisition of wealth and power. However, it’s not without consequences, as shadowy forces attempt to exploit Eddie for their own gain, or kill him in the process. Eddie also begins to experience dangerous side effects, including trip-switching, which causes a stop-motion perception of time.

8. GleeMONEX -Kids in the Hall: Brain Candy

The first (and only) film from The Kids and the Hall revolves around a fictitious company, Roritor Pharmaceuticals, and the development of their groundbreaking antidepressant drug GleeMONEX. Unfortunately, those who use the drug eventually find themselves locked in a comma-like state in which their happiest memory is repeated over and over again. On the plus side, development of the drug led to very few flipper-babies.

7. The Ladder – Jacob’s Ladder

In Jacob’s Ladder, “The Ladder” is a drug developed by the U.S. Military in order to increase aggression in its soldiers. As you’d expect, things don’t go according to plan, and the soldiers end up attacking each other. Those who survive are plagued by terrifying hallucinations.

6. Lot 6 – Firestarter

In Firestarter, Lot 6 (a.k.a. di-lysergic Triune Acid) is a drug, developed by a secret government agency, designed to give recipients telekinetic abilities and the power of mind control. When two test subjects have a child, their offspring ends up with a terrifying pyrokinetic ability, making the child a sought after commodity by a shadowy government agency.

5. Jabroka – Alien Nation

If you’re human, Jabroka probably isn’t the drug for you. After all, it tastes like dish soap, and has no real effect. However, if you’re a Tenctonese alien from the film Alien Nation, this shit will rock your world with feelings of euphoria. But don’t take too much, or you’ll end up a giant out-of-control hulking beast.

4. Skele-Gro – Harry Potter and the Chamber of Secrets

Of all the drugs on this list, Skele-Gro is by far the most useful. Sure, it tastes like garbage, but it literally has the magical ability to regrow bones. Unfortunately, there are no hallucinogenic effects, but oh well. Can’t win ‘em all.

3. Ephemerol – Scanners

Ephemerol was billed as a drug that fights morning sickness. However, unsuspecting moms who used the drug got more than they bargained for. Specifically, children with telepathic powers. The drug was based off the real life drug, Thalidomide, which was found to cause birth defects. I prefer the fictional drug. The ability to make someone’s head explode seems like a much better side effect than deformed limbs.

2. Milk-Plus (Drencrom) – A Clockwork Orange

Aside from random acts of violence, Alex and his Droogs like nothing more than a trip down to the The Korova Milkbar for a spot of Milk-Plus. The drink can be made with many drugs, but Alex prefers Drencrom, which is thought to be the equivalent of the actual drug, Adrenochrome.

1. Nuke – Robocop 2

In Robocop 2, Nuke is a highly addictive synthetic narcotic that is lays waste to the city of Detroit. I understand the need to make the drug as terrifying as possible, but considering crack cocaine’s wildly successful run at destroying the city, I’m not sure a fictional drug was necessary.

When it comes to crime-fighting partnerships, you probably think of Batman and Robin, Starsky and Hutch, Holmes and Watson, etc. You don’t often think of a hard-boiled private detective and a cartoon rabbit, or a regular cop paired with an intergalactic refugee. But in Hollywood, where every idea, no matter how bizarre, will eventually be produced as a major motion picture, these pairings have already occurred. In honor of the release of The Other Guys on Unrated Blu-ray and DVD, we’ve compiled this list of the 9 most awkward crime-fighting partners in movie history.

Eddie Valiant and Roger Rabbit – Who Framed Roger Rabbit (1988)

Eddie Valiant is a hard-nosed, borderline alcoholic private detective who hates cartoons. He blames them for the death of his brother, who was killed by at unknown toon years earlier. So when he finds himsel fighting to clear the name of a cartoon rabbit, things get pretty awkward, pretty fast. Not only is Roger Rabbit’s life at stake, but the fate of Toontown itself also hangs in the balance. For those of you who don’t live in the L.A. area, Toontown is a neighborhood near Hollywood where all the cartoons used to live. It’s since been overrun with Armenians.

Jack Quinn and Yaz – Double Team (1997)

When it comes to pairing celebrities in film, at least one member of the duo should have some acting talent. That way, they can make up for the other’s poor performance. Maybe that’s why Jean-Claude Van Damme and Dennis Rodman are so damn awkward in Double Team. Van Damme plays a counter-terrorism agent, and Rodman plays a drug dealer, but neither of one can act their way out of a paper bag. Granted, I doubt many people went to Double Team to see an Oscar-winning performance, but even so.

Julius and Vincent Benedict – Twins (1988)

Danny Devito and Arnold Schwarzenegger are a pretty awkward pair on their own. But casting them as fraternal twins takes it to a whole new level. While the two don’t start out as crime fighters, circumstances force them to take on a pair of loan shar brothers and a ruthless hitman, so they earned a spot on this prestigious list.

Nick McKenna and Devon Butler – Cop and a Half (1993)

Partnering a grown man with a child is awkward. But partnering a child with a grown man who also has a mustache is downright irresponsible. I know the character’s a cop, but even so, that molester ‘stache is a big red flag. I’m sure Burt Reynolds doesn’t go in for that sort of thing, but the film could lull parents into a false sense of security. The next thing you know, they’ve let their guard down, and the kids are at Jeffrey Jones’s house for another sleepover. Awkward.

Matthew Sykes and Samuel ‘George’ Francisco – Alien Nation (1988)

Alien Nation is a lot like District 9 in the sense that an alien ship becomes stranded on Earth, and humanity has to figure out what to do with the passengers. But unlike District 9, the aliens of Alien Nation are not put in a camp and quarantined. Instead, they are put into a ghetto, just like regular immigrants. Detective Matthews Sykes isn’t big fan of the newcomers, but he teams up with one anyway because it gives him the chance he needs to investigate the murder of his former partner. The two don’t really hit it off, but eventually they learn to respect each other. I guess it’s sort of like The Odd Couple, except with aliens and homicide.

Terry Hoitz and Allen Gamble – The Other Guys (2010)

When you think of action-movie cops, The Rock and Samuel L. Jackson seem like a good pair. But when the characters played by these two are killed off, you’ll have to settle for The Other Guys. Detective Allen Gamble (Will Ferrell) is more interested in pushing paper than pursuing perps, and Detective Terry Hoitz (Mark Wahlberg) is a deranged cop who once shot Derek Jeter during the World Series. Together, they’ll have to unravel a multimillion-dollar conspiracy, and hope that the department will forget the whole “desk pop” thing and allow Gamble to carry his weapon again (instead of a wooden replacement).

Sgt. Joe Bomowski and Tutti Bomowski – Stop! Or My Mom Will Shoot (1992)

So get this! We take Sylvester Stallone and have him play a big tough-guy cop. But we partner him up with…his mom! Crazy, right? I mean, old ladies don’t carry big guns around, so it will be really funny! She’ll be all like, “Honey, be careful, you should eat more,” and stuff, and he’ll be all like “Mom, I’m trying to catch bad guys here.” And then she’ll be like, “I can help,” and he’ll be all like, “Aw mom, no!”

Jake Wilder and Reno – Top Dog (1995)

What could be more awkward than teaming the most powerful man in the world (according to the Internet) with a lovable family pet? Throwing the pair into a plot involving White Supremacists, I suppose. And Top Dog did just that. When an apartment complex full of minorities is destroyed by military-grade explosives, they put Chuck Norris (Jake Wilder) and a dog named Reno on the case. I would have thought the FBI would get involved in something like that, but instead it’s left to a local cop and a dog he doesn’t get along with. Now that’s what I call an awkward partnership.

Dr. Maxwell Kirshner and Jack Moss - The Thing with Two Heads (1972)

Pairing up an old white racist with a black death-row inmate is an awkward concept. Fusing both of their heads onto the same body is a surreal nightmare of racial stereotypes and Hollywood cliches. The old white dude needs a body to stay alive, and the young black “soul brother” needs an excuse to stay out of the electric chair long enough to clear his name. And everyone needs to see this trailer at least once before they die.