A Very Harold & Kumar Christmas is coming to a Blu-ray player near you, but drug abuse is no laughing matter. Well, OK, In movies, drug abuse is sometimes a laughing matter, at least if these characters are involved. They make us laugh, they make us cry, they might even get us a contact high (whoa - that, like, rhymes). Just don't try to use them as a reference for a job application. Here are seven of the greatest drug-abusing duos of in cinema history.

Cheech and Chong

Cheech Marin and Tommy Chong are one of the most famous comedy duos in history. They would probably scoff at being called drug abusers - how can you call it abuse when the relationship is so harmonious, man? - but their status as one of the great drug using duos of all time is unquestionable.

Nick and Nora Charles

Alcohol is a kind of drug, right? And nobody ever drank better than the elegant super-sleuth and his even-more elegant wife in the Thin Man movies from the 1930s and 40s. They don't get drunk, per se - just tipsy enough to see everything clearly and to keep the banter flowing. The movies' treatment of what we now refer to as "alcoholism" might not be politically correct by today's standards, but they're still the most fun you can have without drinking.

Dale and Saul

Played by Seth Rogen and James Franco in Pineapple Express, Dale and Saul typify the buyer/dealer relationship: The dealer wants to chill and hang out, while the buyer just wants to get his weed and go home. At least until Dale becomes an accidental witness to a murder and is forced to go to his dealer for help. Then, they do what so few potheads actually do: Become action movie heroes.

Raoul Duke and Dr. Gonzo

Based on writer Hunter S. Thompson and his attorney Oscar, Raoul and the doc (as played by Johnny Depp and Benicio del Toro) are on all kinds of mind-altering substances throughout the movie Fear and Loathing in Las Vegas. By the time it's over, the people watching might feel like they are, too. Depp and del Toro are both great actors, so it should be no surprise that they make one of the best drug-abusing duos in movie history.

Dick Ritchie and Floyd

The two Hollywood roommates in True Romance have pretty distinct lifestyles: Dick is a struggling actor, while Floyd is a non-struggling couch inhabitant. So, they only get one or two scenes together, but they're so funny that it's enough to qualify them as a great drug-using duo. Plus, Brad Pitt's Floyd served as part of the inspiration for Pineapple Express.

Harry and Tyrone

Unlike most of these other movies, Requiem for a Dream is NOT trying to make you laugh. I think the funniest thing that happens in it is an amputation. But Jared Leto's Harry and Marlon Wayans' Tyrone are great to watch together because of the friendship between the characters. This friendship is of course completely shattered by drug abuse and crime in one of the most depressing stories ever put on film, but still.

Louis and Melanie

Robert De Niro and Bridget Fonda might not seem like a likely pair, but they make a good one in Quentin Tarantino's Jackie Brown, in part thanks to the magical properties of marijuana. Also because neither of them have anything better to do than hang out, watch TV, and bang in between capers. But what the two lack in conventional chemistry they make up for, I'm just not sure how. Here's to friends!

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