The 10 most famous movie duos ever comprise what has become the "buddy movie" formula. Take a mismatched pair guys and set them off on an adventure and watch a great friendship form. That's not the case with all of the ten most famous movie duos listed here, but you'll definitely notice a pattern as you review some of the great movie teams of all time.

  1. Robert Redford and Paul Newman. They defined the buddy adventure movie with the classic Western, "Butch Cassidy and the Sundance Kid," and then teamed up again a few years later for another beloved movie, "The Sting." Their chemistry was appealing and their performances looked effortless. Too bad they couldn't get together one more big heist.

  2. Mel Gibson and Danny Glover. When "Lethal Weapon" was first released in 1987, skeptics looked at it like yet another cop movie about a by-the-book veteran teamed up with a crazy young cop-who-doesn't-play-by-the-rules. But Gibson and Glover were such a cool team and the movie was such a big hit that three sequels followed and those guys wound up defining that type of detective team-up forever.

  3. The Blues Brothers. Dan Aykroyd and John Belushi only appeared together in one film as Jake and Elwood Blues, but the resulting John Landis-directed musical-comedy, teeming with cameos, was a wild ride and makes you wonder if more Blue Brothers movies could have been just as much fun had Belushi not checked out in 1982.

  4. Buzz and Woody. The starring toys in Pixar's "Toy Story" franchise, voiced by Tim Allen and Tom Hanks, may turn out to be among the most enduring movie duos ever, thanks to the new generations of kids who continue to discover these amazing films."

  5. Susan Sarandon and Geen Davis. The stars of "Thelma and Louise" became one of the first set of actresses to star in a successful "buddy movie," albeit one that didn't leave a lot of room for a sequel.

  6. Kirk and Spock. The "Star Trek" franchise started as a short-lived 1960s TV series, but wound up producing several other TV series and movies with a variety of casts. Whether it was William Shatner and Leonard Nimoy on the Enterprise or their younger versions, Chris Pine and Zachary Quinto, the Kirk and Spock team is one of the best in modern movies.

  7. Jack Lemmon and Walter Matthau. The Hollywood legends teamed up in ten movies, starting with "The Fortune Cookie" in 1966 and "The Odd Couple" in 1967 and ending with "The Odd Couple II" in 1998. Lemmon's high-strung persona and Mathau's basset hound demeanor were a perfect match. They mined movie comedy gold for an impressive 30 years.

  8. Martin and Lewis. It may be hard to imagine these days, but from 1946 to 1956, the team of Dean Martin and Jerry Lewis was one of the biggest deals in show business. They played sold-out live gigs and made seventeen movies together, with Martin as the romantic leading man (a role he tired of and which eventually led to their famous split) and Lewis as the crazy comedian. Watch some of their early movies like "Sailor Beware" and "The Caddy" to see just how funny these guys were.

  9. Tommy Lee Jones and Will Smith. Great movie duos are often the result of the right casting and whoever paired Smith and Jones for the "Men in Black" films deserves a prize. Jones' cynical and weary veteran and Smith's unconventional and naive newcomer made for one of the most appealing duos in a long time.

  10. David Spade and Chris Farley. Sadly, the former "Saturday Night Live" co-stars only appeared in two films together. The hilarious road trip comedy "Tommy Boy" and slightly uneven "Black Sheep" were envisioned to be just the beginning for this pair. But Farley's untimely death at age 33 made future films impossible.