Characterized by exhilarating storylines and award winning performances by actors Kevin Spacey and Sean Connery, the 10 best medical thrillers include James Whale’s 1931 classic “Frankenstein” and Robert Wiene’s 1920 masterpiece “The Cabinet of Dr. Caligari,” a film considered by most to be the first film ever to employ the “twist ending” and one of the most influential movies in the history of film.

  1. "The Cabinet of Dr. Caligari" One of the most influential silent films ever produced, this 1920 masterpiece by German director Robert Wiene about the head of an insane asylum who controls his patients through willpower is one of the ten best medical thrillers in the history of film.

  2. "Flatliners" Featuring powerful early performances by an amazing ensemble cast of actors including Kiefer Sutherland, Julia Roberts and Kevin Bacon, this film about a group of medical students who attempt to find out what happens after death has become a cult classic.

  3. "Shutter Island" One of the ten best medical thrillers in recent years, this 2010 film by acclaimed director Martin Scorsese about two U.S. Marshals investigating a psychiatric facility features mind-bending plot twists and excellent performances by character actors Jackie Earle Haley and Elias Koteas.

  4. "Extreme Measures" A strange medical thriller about a doctor who experiments on the homeless in an effort to find a cure for paralysis, this stirring film delivers excellent performances by actors Hugh Grant and screen veteran Gene Hackman. The film is highlight by powerful cameo performances by character actors David Morse and J. K. Simmons.

  5. "Jacob’s Ladder" One of the ten best medical thrillers about the Vietnam War, this bizarre and nightmarish film about experimental treatments performed on former veterans features one of the best twist endings in film. Career-defining performances by actors Tim Robbins and Danny Aiello highlight this disturbing thriller.

  6. "Medicine Man" One of the ten best medical thrillers of the 1990’s, this film features an amazing performance by Sean Connery as Dr. Robert Campbell, a scientist in the Amazon Rainforest racing against the clock to find a cure for cancer before a logging company destroys the village he has sworn to save.

  7. "Awake" A strange film about a man who experiences anesthesia awareness and remains awake during surgery only to uncover a plot to kill him, “Awake” features impeccable dialogue written by writer-director Toby Harold. This face-paced thriller is highlighted by dramatic performances by actors Haden Christiansen and Jessica Alba.

  8. "Frankenstein" One of the ten best medical thrillers of all time, this classic by director James Whale about a mad scientist who pieces together a human body and reanimates the corpse through electricity remains one of Universal Pictures and actor Boris Karloff’s most famous and enduring films.

  9. "Repo! The Genetic Opera" One of the ten best medical thrillers in recent years, this musical about a dystopian world in which organs are transplanted and repossessed for profit features energetic musical numbers by actors like Anthony Stewart Head and Paul Sorvino. With a total of 64 musical numbers, the film holds the record for the most songs ever composed into one film.

  10. "Outbreak" A critically acclaimed film about the outbreak of a fictional virus and the doctors who race to contain it, “Outbreak” features career-defining performances by actors Dustin Hoffman and Rene Russo, as well as screen legend Morgan Freeman and Academy Award winner Cuba Gooding, Jr. The film earned a number of independent award nominations, including a number of awards for actor Kevin Spacey for his excellent turn as Major Casey Schuler.