"How do you make so many people love you without affecting Free Will?" – Bruce. This "Bruce Almighty" quote was a question that Bruce asked God when he realized that he was not satisfying everyone's prayers. It was the moment that he became aware of how difficult it is for God to give everyone what they want. It can not always happen that way, but everything happens for a reason. God has a plan; people just do not realize what that plan is until they are able to open their eyes and see it.
"You can't kneel down in the middle of a highway and live to talk about it, son." – God. Bruce has hit rock bottom and finally decides that he is going to pray to God. However, he decided to do it right in the middle of the highway! When he asks God if he is dead, this "Bruce Almighty" quote was God's reply. You really can not kneel in the middle of a highway and live to talk about it!
"I did the same thing to Gandhi, he didn't eat for three weeks." – God. This "Bruce Almighty" quote shows God with a bit of a sense of humor. This is when God gives Bruce seven fingers and it freaked him out. God was making a joke out of Bruce's shock.
"Okay Cool, man, the day a monkey comes out of my butt is the day you'll get your sorry." – Hood. Bruce witnesses a bunch of guys beating someone up. Since he has God's powers, he feels he is able to do something about this. After one of the guys says this quote, Bruce actually makes it a reality. He makes a monkey come out of the guy's butt!